英文名稱    MKP1   

中文名稱    絲裂原活化蛋白激酶磷酸酶-1抗體

別    名    DUSP1; Mitogen activated protein kinase phosphatase 1; CL 100; CL100; Dual Specificity Phosphatase 1; Dual specificity protein phosphatase 1; Dual specificity protein phosphatase hVH1; DUSP 1; DUSP-1; EC 3.1.3.16; EC 3.1.3.48; HVH 1; HVH1; MAP kinase phosphatase 1; MKP 1; MKP1; MKP-1; Protein tyrosine phosphatase CL100; PTPN 10; PTPN10; Serine/threonine specific protein phosphatase; VH 1; VH1; 3ch134; Mkp1; Ptpn16.

供 應 商    遠慕生物

研究領域    腫瘤  免疫學  信號轉導  細胞凋亡  轉錄調節因子

抗體來源    Rabbit

克隆類型    Polyclonal

交叉反應    Human, Mouse, Rat, Cow, Horse, Sheep,

產品應用    WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:400-800 IHC-F=1:400-800 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

分 子 量    39kDa

細胞定位    細胞核

性    狀    Lyophilized or Liquid

濃    度    1mg/ml

免 疫 原    KLH conjugated synthetic peptide derived from human MKP1:101-200/367

亞    型    IgG

純化方法    affinity purified by Protein A

儲 存 液    Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4

保存條件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

絲裂原活化蛋白激酶磷酸酶-1抗體產品說明

MKPs是一類絲/氨酸/蘇氨/酸和酪氨/酸雙重底物特異性的磷酸酶 ,對于絲裂素活化蛋白激酶活性的調節起著十分重要的作用，可使絲裂素活化蛋白激酶上的蘇氨/酸/酪氨/酸去磷酸化失活。目前研究發現MKPs分別有MKP-1、MKP-2、MKP-3及MKP4-6。

MKPs受MAPK信號通路中多種成分的誘導 ,決定了它與MAPK之間作用的特異性。 通過去磷酸化作用調節MAPK信號途徑的活性 ,確保了細胞內信號的精確傳遞 ,參與了多種主要的細胞功能的調節。

The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation.

mol wt:40kDa

Other Aliases:

Mitogen activated protein kinase phosphatase 1; CL 100; CL100; Dual Specificity Phosphatase 1; Dual specificity protein phosphatase 1; Dual specificity protein phosphatase hVH1; DUSP 1; EC 3.1.3.16; EC 3.1.3.48; HVH 1; HVH1; MAP kinase phosphatase 1; MKP 1; MKP1; Protein tyrosine phosphatase CL100; PTPN 10; PTPN10; Serine/threonine specific protein phosphatase; VH 1; VH1; 3ch134; Mkp1; Ptpn16