英文名稱    ETFB    

中文名稱    電子轉移黃素蛋白β肽/黃素蛋白抗體    

別    名    Flavoprotein; Beta ETF; FP; Beta-ETF; Electron transfer flavoprotein beta polypeptide; Electron transfer flavoprotein beta subunit; Electron transfer flavoprotein subunit beta; Electron transferring flavoprotein beta polypeptide; etfB; ETFB_HUMAN; FP585; MADD.    

供 應 商    遠慕生物

研究領域    腫瘤  細胞生物  免疫學  信號轉導  轉錄調節因子  線粒體      

抗體來源    Rabbit    

克隆類型    Polyclonal    

交叉反應    Human, Mouse, Rat, Dog, Pig, Cow,     

產品應用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 電子轉移黃素蛋白β肽/黃素蛋白抗體（石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.    

分 子 量    28kDa    

細胞定位    細胞漿 線粒體    

性    狀    Lyophilized or Liquid    

濃    度    1mg/1ml    

免 疫 原    KLH conjugated synthetic peptide derived from human ETFB    

亞    型    IgG    

純化方法    affinity purified by Protein A    

儲 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide    

保存條件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.    

電子轉移黃素蛋白β肽/黃素蛋白抗體產品介紹    background:

The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase.

Function:
The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase).

Subunit:
Heterodimer of an alpha and a beta subunit.

Subcellular Location:
Mitochondrion matrix.

Tissue Specificity:
Abundant in liver, heart and skeletal muscle. A weak expression is seen in the brain, placenta, lung, kidney and pancreas.

DISEASE:
Defects in ETFB are the cause of glutaric aciduria type 2B (GA2B) [MIM:231680]. GA2B is an autosomal recessively inherited disorder of fatty acid, amino acid, and choline metabolism. It is characterized by multiple acyl-CoA dehydrogenase deficiencies resulting in large excretion not only of glutaric acid, but also of lactic, ethylmalonic, butyric, isobutyric, 2-methyl-butyric, and isovaleric acids.

Similarity:
Belongs to the ETF beta-subunit/fixA family.

Database links:
UniProtKB/Swiss-Prot: P38117.3

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.